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The α1-Antitrypsin Clearance ELISA kit is an enzyme immunoassay intended for the quantitative determination of α1-Antitrypsin in serum, plasma and stool.

Various gastrointestinal diseases (e. g. allergies, chronic inflammation, malignancies) damage the mucosal integrity and/or cause lymphostasis, thereby leading to an increased transfer of plasma proteins into the bowel lumen.

An elevated α1-antitrypsin stool concentration is therefore a widely recognised marker for intestinal protein loss and for an increased mucosal permeability.

The EDN ELISA kit is designed to quantify eosinophilic neurotoxin (eosinophilderived neurotoxin (EDN)), also known as RNASE2 or eosinophilic protein X (EPX) in human serum / plasma, urine and stool.

Indications:

• Crohn's disease;

• Proof of a food allergy and incompatibility;

• Assessment of an elimination diet;

• Proof of damaged integrity of the intestinal mucous membrane (e. g. chronic inflammatory bowel disease, colon cancer);

• Proof of intestinal parasites / parasitoses.

The EDN ELISA kit is designed to quantify eosinophilic neurotoxin (eosinophilderived neurotoxin (EDN)), also known as RNASE2 or eosinophilic protein X (EPX) in human serum / plasma, urine and stool.

Indications:

• Crohn's disease;

• Proof of a food allergy and incompatibility;

• Assessment of an elimination diet;

• Proof of damaged integrity of the intestinal mucous membrane (e. g. chronic inflammatory bowel disease, colon cancer);

• Proof of intestinal parasites / parasitoses.

The MPO ELISA kit is an enzyme immunoassay intended for the quantitative determination of myeloperoxidase (MPO) in urine and stool. 

Myeloperoxidase (MPO) catalyses the oxidation of substances through H2O2. The MPO H2O2–system has a toxic effect on many micro-organisms such as bacteria, fungi, viruses and mycoplasma. The efficiency of the bacteria-destructive myeloperoxidase H2O2–system is increased by PMN-Elastase.

Indications:

• Marker for inflammatory activities in the gastrointestinal tract (Stool);

• Renal transplant rejection (Urine);

• Oxidative stress (Serum);

• For the differentiation between allergic and infectious asthma (bronchial lavage, respiratory condensate, sputum);

• Prediction of risk in patients with acute coronary syndromes (Serum).

The MPO ELISA kit is intended for the quantitative determination of myeloperoxidase (myeloperoxidase (MPO)) in human serum and plasma.

Indications:

• Marker for inflammatory activities in the gastrointestinal tract (Stool);

• Renal transplant rejection (Urine);

• Oxidative stress (Serum);

• For the differentiation between allergic and infectious asthma (bronchial lavage, respiratory condensate, sputum);

• Prediction of risk in patients with acute coronary syndromes (Serum).

The ß2 - Microglobulin ELISA kit is an enzyme immunoassay intended for the quantitative determination of ß2-microglobulin in serum, plasma and urine. 

ß2-microglobulin is a protein and is found on the cell membrane of all nucleated cells. This protein is metabolised extensively in the kidney.

The serum concentration is influenced by the rates of synthesis and metabolism and is usually stable in healthy persons. Changes in the serum concentrations are indicative of disorders in glomerular and tubular functions.

Serum β2-microglobulin is used as a prognostic tumor marker in oncohematology.

The α2-Macroglobulin ELISA kit is intended for the quantitative determination of α2-macroglobulin in urine, serum and plasma. 

Indications:

• Detection and differentiation of proteinuria according to kidney damage localisation;

• Differentiation of renal and postrenal hematuria.

Detecting α2M in urine is evidence of postrenal damage, when unfiltered serum proteins leak into the urine. Causes of postrenal damage are inflammation or hematuria as a consequence of renal stones or carcinomas.

The β-Defensin 2 ELISA kit is intended for the quantitative determination of β-defensin 2 in stool. 

Defensins exert a variable degree of antimicrobial activity against bacteria, fungi, and some enveloped viruses. The expression of ß-defensins is induced by the proinflammatory cytokines and also through microorganisms (e.g. E. coli, H. pylori or P. aeruginosa).

A ß-defensin 2 deficiency can, for example, be observed in the intestinal mucous of patients with Crohn’s disease. 

The Pancreatic amylase ELISA kit is an enzyme immunoassay intended for the quantitative determination of pancreatic amylase in stool. 

Like lipase and elastase, the pancreatic amylase is synthesised in the pancreas. In case of a chronic pancreatitis, pancreatic amylase is decreased.

Indications:

• Chronic pancreatitis;

• Exocrine pancreatic insufficiency.

The Prealbumin (transthyretin) ELISA kit is intended for the quantitative determination of prealbumin (transthyretin) in serum, plasma, urine and stool. 

Prealbumin (transthyretin) is a transport protein secreted in the liver, brain and retina. It transports thyroxin (T4) and retinol binding protein in serum and cerebrospinal fluid. 

Transthyretin is reduced in inflammatory reactions and is therefor an acutephase protein. A mutation in the transthyretin gene can result in a chronically lowered transthyretin level in the blood, leading to amyloidosis. As transthyretin is the protein with the highest proportion of essential amino acids and has a rather short biological halflife of 1–2 days, it can be used for the diagnosis of malnourishment and distur-bances of the metabolic pathways in the liver.

The Albumin ELISA kit is an enzyme immunoassay intended for the quantitative determination of albumin in urine and stool.

Albumin is the major protein in human plasma. Changes in the concentration of albumin in urine and faeces are a result of distribution disorder, less synthesis problems. Stronger albumin loss leads to increased synthesis, for example in case of nephrotic syndrome.

Elevated levels of albumin and hemoglobin in stool are observed not only in colorectal carcinomas, but also in polyps and during chronic inflammatory diseases (Morbus Crohn or Colitis Ulcerosa). Albumin in faecal samples refers to an inflammatory reaction combined with intestinal bleeding. 

The Adiponectin (total) ELISA kit is an enzyme immunoassay intended for the quantitative determination of adiponectin in serum and plasma. 

Adiponectin levels are associated with insulin resistance and, accordingly, are associated with type 2 diabetes. The higher the level of adiponectin in the blood, the lower the risk of developing type 2 diabetes, regardless of body mass index (BMI), race and gender.

In addition, it is involved in inflammatory processes and, therefore, is important for the development of atherosclerosis and coronary artery disease.

The Hemoglobin ELISA kit is designed to quantify human hemoglobin (Hb) in stool (colorectal cancer screening).

Indications:

• Crohn's disease; Ulcerative Colitis;

• Suspicion of colon carcinoma;

• Polyps in the colon.

The Hb / Hp complex ELISA kit is designed to quantify the hemoglobin / haptoglobin (Hb / Hp) complex in human stool.

Hemoglobin/haptoglobin complex determination increases the clinical specificity and sensitivity.

Indications:

• Crohn's disease; Ulcerative Colitis;

• Suspicion of colon carcinoma;

• Polyps in the colon.