Zonulin ELISA

The Zonulin ELISA kit is intended for the quantitative determination of zonulin family peptides (ZFP) in serum. 

Zonulin is a human protein which regulates tight junctions of the digestive tract. Zonulin binds to a specific receptor on the surface of intestinal epithelia and triggers a cascade of biochemical events which induces tight junction disassembly and a subsequent permeability increase of the intestinal epithelia, allowing some substances to pass through and activate immune reactions.

The zonulin system is more activated in celiac disease and type 1 diabetes mellitus patients. 

An increased intestinal permeability, also colloquially called ‘leaky gut’, is nowadays associated with the metabolic syndrome, obesity, and several autoimmune, inflammatory, and neoplastic diseases.