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The Osteoprotegerin (OPG) ELISA kit is a sandwich ELISA intended for the quantitative determination of osteoprotegerin in serum, EDTA plasma, heparin plasma or citrate plasma. 

Osteoprotegerin (OPG) or osteoclast inhibitory factor (OCIF) is a glycoprotein produced by many different tissues and cell types including osteoblasts.

OPG is a negative regulator of bone resorption by acting as decoy receptor for RANKL, thus neutralizing its function in osteoclastogenesis. This glycoprotein is also involved in the regulation of vascular calcification.

The ADMA ELISA kit is intended for the quantitative determination of asymmetric dimethyl-L-arginine (ADMA) in human serum, citrate and EDTA plasma. 

Elevated ADMA concentrations in the blood are found in numerous diseases associated with endothelial dysfunction. For example, elevated ADMA levels in blood of dialysis patients correlate significantly with the degree of arteriosclerosis and cardiovascular risk.

Furthermore, elevated ADMA levels are found in patients with hypercholesterolemia, hypertension, arteriosclerosis, chronic renal failure and chronic heart failure, and are associated with restrictions in endothelial vasodilatation. 

The SDMA ELISA kit is intended for the quantitative determination of symmetrical dimethyarginine (symmetrical dimethylarginine (SDMA)) in human, canine and feline serum, EDTA and Li-heparin plasma.

SDMA is a methylated derivative of L-arginine which is strictly eliminated by renal extraction, thus the SDMA plasma level is strongly correlated to renal function. 

Indication:

· Renal failure;

· Cardiovascular risk in renal dysfunction;

· Hypertension in renal dysfunction.