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The 25-OH Vitamin D ELISA test kit is designed for the determination of 25 (OH) vitamin D in human serum or plasma samples. Indication: Suspected vitamin D deficiency or overdosing, reduced intestinal vitamin D uptake, hypocalcaemia, hypophosphataemia, hypocalciuria, elevated alkaline phosphatase, reduced bone mineral content.

The Osteoprotegerin (OPG) ELISA kit is a sandwich ELISA intended for the quantitative determination of osteoprotegerin in serum, EDTA plasma, heparin plasma or citrate plasma. 

Osteoprotegerin (OPG) or osteoclast inhibitory factor (OCIF) is a glycoprotein produced by many different tissues and cell types including osteoblasts.

OPG is a negative regulator of bone resorption by acting as decoy receptor for RANKL, thus neutralizing its function in osteoclastogenesis. This glycoprotein is also involved in the regulation of vascular calcification.

The total sRANKL (human) ELISA kit is intended for the quantitative determination of of total sRANKL (human) in serum and plasma, i.e. free sRANKL as well as sRANKL bound to OPG. 

Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL) is a transmembrane protein produced by osteocytes and is part of the tumor necrosis factor (TNF) family. It is the main stimulant for osteoclast formation and is essential for their survival.

RANKL expression leads to bone reabsorption and loss which is counteracted by osteoprotegerin (OPG). RANKL/OPG regulate bone remodeling and an imbalance may lead to bone metabolic diseases.

The 25 (OH) Vitamin D direct day ELISA kit is intended for the quantitative determination of 25 (OH) - vitamin D in serum and fresh human blood plasma.

Vitamin D regulates intestinal calcium resorption, bone mineralization, osteoblast differentiation, and bone matrix synthesis. 25 (OH) Vitamin D form is obtained after hydroxylation of Carbon 25 in the liver: this is the main form present in the circulating system, and its levels are use as an indicator for the general Vitamin D status of an individual.

Vitamin D deficiency has been associated to many diseases such as osteoporosis, rickets, osteomalacia, cancers and cardiovascular disease.

The 25 (OH) Vitamin D dried blood ELISA kit s intended for the quantitative determination of the 25 (OH) Vitamin D in dried blood. 

Vitamin D regulates intestinal calcium resorption, bone mineralization, osteoblast differentiation, and bone matrix synthesis. 25 (OH) Vitamin D form is obtained after hydroxylation of Carbon 25 in the liver: this is the main form present in the circulating system, and its levels are use as an indicator for the general Vitamin D status of an individual.

Vitamin D deficiency has been associated to many diseases such as osteoporosis, rickets, osteomalacia, cancers and cardiovascular disease.

The 1,25 (OH) 2 Vitamin D ELISA Kit is intended for the quantitative determination of 1,25-dihydroxyvitamin D in serum and plasma. 

1,25 (OH) 2 Vitamin D is formed in a second hydroxylation step in the kidney. The responsible enzyme, the kidney 1α-hydroxylase, is subjected to a rigid control through hormones (especially parathyroid hormone) and its activity is influenced by the serum concentrations of calcium and phosphate.

Indications:

• Defect of kidney function
• Chronic kidney failure
• Haemodialysis following kidney transplantation
• Renal osteopathy
• Osteomalacia from various types of vitamin D metabolism disturbances
• Kidney tubules function disturbances (diabetes insipidus, Fanconi-Syndrom)
• Monitoring of therapy with active vitamin D metabolites
• Ideopathic hypercalciuria
• Hypercalcaemia

The VDBP ELISA kit is an enzyme immunoassay intended for the quantitative determination of free and not actin complex bound vitamin D binding protein (VDBP) in serum, plasma and urine. 

In the blood, VDBP binds the bigger part of the circulating 25 (OH) vitamin D and brings it to the kidneys, where it is transformed into the hormone 1,25 (OH) 2 vitamin D.